Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells

BackgroundNeuroblastoma (NB) is characterized by both adrenergic (ADRN) and undifferentiated mesenchymal (MES) subsets. The ganglioside sialic acid-containing glycosphingolipid (GD2) is widely overexpressed on tumors of neuroectodermal origin promoting malignant phenotypes. MES cells are greatly enr...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Sabina Di Matteo, Maria Teresa Bilotta, Andrea Pelosi, Dorothee Haas, Tobias Theinert, Gerrit Weber, Paul-Gerhardt Schlegel, Matthias Berg, Lorenzo Moretta, Enrico Maggi, Bruno Azzarone, Paola Vacca, Nicola Tumino, Ignazio Caruana
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	neuroblastoma ganglioside sialic acid-containing glycosphingolipid-2 NK cells immunotherapy primary tumor cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1382931/full