Metformin-associated gut microbiota remodeling correlates with reinvigorated splenic immunity in aged mice: microbiome-immune crosstalk via the gut-spleen axis

Background and aimImmunosenescence involves age-related immune decline and chronic inflammation, with the spleen serving as a critical hub for immune dysregulation. While gut microbiota influences systemic immunity, its specific role and the potential existence of a gut-spleen axis in mediating sple...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Shu-Qin Ding, Xin-Yi Lyu, Shi-Yu Zhou, Yi-Wan Fang, Hao-Xin Ji, Jiang-Yan Li, He-Zuo Lü
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	metformin gut microbiota immunosenescence microbiome-immune crosstalk gut-spleen axis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1633486/full