Attenuated T cell responses to a high-potency ligand in vivo.

αβ T cell receptor (TCR) recognition of foreign peptides bound to major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells is a key event in the initiation of adaptive cellular immunity. In vitro, high-affinity binding and/or long-lived interactions between TCRs a...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Emily Corse, Rachel A Gottschalk, Michelle Krogsgaard, James P Allison
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-09-01
Online Access:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000481&type=printable