Identification of a rare variant in TNNT3 responsible for familial dilated cardiomyopathy through whole-exome sequencing and in silico analysis

Abstract Background Dilated cardiomyopathy (DCM) is a prevalent etiology of heart failure, distinguished by the gradual and frequently irreversible myocardial muscle impairment. Roughly 50% of DCM occurrences stem from hereditary rare variants. In this study, our aim was to identify the genetic caus...

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Bibliographic Details

Published in:	European Journal of Medical Research
Main Authors:	Motahareh Jadidi, Vida Babaali, Kolsoum InanlooRahatloo, Najmeh Salehi, Reza Mollazadeh
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Dilated cardiomyopathy DCM Whole-exome sequencing Troponin T TNNT3
Online Access:	https://doi.org/10.1186/s40001-025-02692-3