Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging

Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study uses magnetic resonance imaging (MRI) techniques to...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Subjects:	dynamic colon model (DCM) large intestine colon colon-specific drug formulations colonic flow phase contrast cine-MRI
Online Access:	https://www.mdpi.com/1999-4923/13/10/1545