Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Abstract Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a...

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Bibliographic Details

Published in:	Journal of Cachexia, Sarcopenia and Muscle
Main Authors:	Sara Chiappalupi, Guglielmo Sorci, Aleksandra Vukasinovic, Laura Salvadori, Roberta Sagheddu, Dario Coletti, Giorgia Renga, Luigina Romani, Rosario Donato, Francesca Riuzzi
Format:	Article
Language:	English
Published:	Wiley 2020-08-01
Subjects:	Cancer cachexia RAGE Inflammation Muscle atrophy S100B HMGB1
Online Access:	https://doi.org/10.1002/jcsm.12561