Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways

Abstract Developmental neurotoxicity (DNT) induced by sevoflurane exposure poses significant risks to pediatric anesthesia, yet effective protective strategies remain limited. Here, we developed self-assembling Angiopep-2/SIRT1 nanoparticles (Ang/SIRT1-NPs) with favorable biocompatibility and brain-...

Full description

Bibliographic Details
Published in:Journal of Nanobiotechnology
Main Authors: Yi Chang, Xue Zhang, Shuo Zhang, Ge Qu
Format: Article
Language:English
Published: BMC 2025-08-01
Subjects:
Sevoflurane
Developmental neurotoxicity
Angiopep-2/SIRT1 nanoparticles
Necroptosis
Multi-omics
Online Access:https://doi.org/10.1186/s12951-025-03639-w

Internet

https://doi.org/10.1186/s12951-025-03639-w

Similar Items