Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.

BACKGROUND:The tumor suppressor homeodomain-interacting protein kinase-2 (HIPK2) by phosphorylating serine 46 (Ser46) is a crucial regulator of p53 apoptotic function. HIPK2 is also a transcriptional co-repressor of hypoxia-inducible factor-1alpha (HIF-1alpha) restraining tumor angiogenesis and chem...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Lavinia Nardinocchi, Rosa Puca, Ada Sacchi, Gideon Rechavi, David Givol, Gabriella D'Orazi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-08-01
Online Access:	http://europepmc.org/articles/PMC2729407?pdf=render