Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

Evolutionary innovations that enable organisms to colonize new ecological niches are rare compared to gradual evolutionary changes in existing traits. We discovered that key mutations in the gltA gene, which encodes citrate synthase (CS), occurred both before and after Escherichia coli gained the ab...

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发表在:	eLife
Main Authors:	Erik M Quandt, Jimmy Gollihar, Zachary D Blount, Andrew D Ellington, George Georgiou, Jeffrey E Barrick
格式:	文件
语言:	英语
出版:	eLife Sciences Publications Ltd 2015-10-01
主题:	evolutionary innovation epistasis experimental evolution flux balance analysis metabolic network genetic basis of adaptation
在线阅读:	https://elifesciences.org/articles/09696