PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1

Abstract Background Spermatogonial stem cells (SSCs) are essential for the maintenance and initiation of male spermatogenesis. Despite the advances in understanding SSC biology in mouse models, the mechanisms underlying human SSC development remain elusive. Results Here, we analyzed the signaling pa...

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Bibliographic Details
Published in:Biological Research
Main Authors: Xueheng Zhao, Lvjun Liu, Zenghui Huang, Fang Zhu, Huan Zhang, Dai Zhou
Format: Article
Language:English
Published: BMC 2024-09-01
Subjects:
Spermatogonial stem cells
Proliferation
Apoptosis
Self-renewal
Pleiotrophin
Syndecan-2
Online Access:https://doi.org/10.1186/s40659-024-00546-6

Internet

https://doi.org/10.1186/s40659-024-00546-6

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