Serum vesicle biomarkers reflect the disease activity of idiopathic pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease caused by an interplay of genetic and environmental factors. Biomarkers that reflect the progression of fibrosis are required for the management of IPF. Methods We extracted serum extracellular vesicles from a discove...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Yuya Shirai, Takatoshi Enomoto, Yoshito Takeda, Ryuya Edahiro, Miho Takahashi-Itoh, Yoshimi Noda, Yuichi Adachi, Mana Nakayama, Takahiro Kawasaki, Taro Koba, Yu Futami, Hanako Yoshimura, Saori Amiya, Reina Hara, Makoto Yamamoto, Daisuke Nakatsubo, Yasuhiko Suga, Maiko Naito, Kentaro Masuhiro, Takanori Matsuki, Haruhiko Hirata, Kota Iwahori, Izumi Nagatomo, Kotaro Miyake, Shohei Koyama, Kiyoharu Fukushima, Takayuki Shiroyama, Yujiro Naito, Shinji Futami, Yayoi Natsume-Kitatani, Naoko Ose, Soichiro Funaki, Satoshi Nojima, Shigeyuki Shichino, Masahiro Yanagawa, Yasushi Shintani, Mari Nogami-Itoh, Jun Adachi, Yoshikazu Inoue, Takeshi Tomonaga, Yukinori Okada, Kenji Mizuguchi, Atsushi Kumanogoh
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Idiopathic pulmonary fibrosis Non-target proteomics Extracellular vesicles SFTPB
Online Access:	https://doi.org/10.1186/s12967-025-07011-2