An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase.

TMEM16 proteins are a recently identified protein family comprising Ca2+-activated Cl- channels that generate outwardly rectifying ionic currents in response to intracellular Ca2+ elevations. Some TMEM16 family members, such as TMEM16F/ANO6 are also essential for Ca2+-dependent phospholipid scrambli...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Thomas Pelz, Daniela R Drose, David Fleck, Bastian Henkel, Tobias Ackels, Marc Spehr, Eva M Neuhaus
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	http://europepmc.org/articles/PMC5812556?pdf=render