PIPENN-EMB ensemble net and protein embeddings generalise protein interface prediction beyond homology

Abstract Protein interactions are crucial for understanding biological functions and disease mechanisms, but predicting these remains a complex task in computational biology. Increasingly, Deep Learning models are having success in interface prediction. This study presents PIPENN-EMB which explores...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	David P. G. Thomas, Carlos M. Garcia Fernandez, Reza Haydarlou, K. Anton Feenstra
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Subjects:	Protein interface prediction Protein–protein interactions Sequence-based prediction PPI Embedding
Online Access:	https://doi.org/10.1038/s41598-025-88445-y