Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition

Chronic intermittent hypoxia (CIH), the main attribute of obstructive sleep apnea (OSA), produces oxidative stress, endothelial dysfunction, and hypertension. Nitric oxide (NO) plays a critical role in controlling the vasomotor tone. The NO level depends on the L-arginine level, which can be reduced...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Bernardo J. Krause, Paola Casanello, Ana C. Dias, Paulina Arias, Victoria Velarde, German A. Arenas, Marcelo D. Preite, Rodrigo Iturriaga
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-07-01
Subjects:	arginase chronic intermittent hypoxia endothelial dysfunction nitric oxide oxidative stress vascular reactivity
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2018.00901/full