Role of BACE1 in Alzheimer’s synaptic function

Abstract Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary tangles. Although the exact etiology of AD remains a mystery, studies over the pas...

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Bibliographic Details
Published in:Translational Neurodegeneration
Main Authors: Brati Das, Riqiang Yan
Format: Article
Language:English
Published: BMC 2017-08-01
Subjects:
Amyloid deposition
β-amyloid peptide
BACE1
Secretase
BACE1 substrates
Synaptic functions
Online Access:http://link.springer.com/article/10.1186/s40035-017-0093-5

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http://link.springer.com/article/10.1186/s40035-017-0093-5

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