Profiling of extracellular vesicles from primary hepatocytes, organoids, and mash patients identifies cell injury-specific signatures

Abstract Metabolic Dysfunction-Associated Steatohepatitis (MASH) is a severe form of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), traditionally diagnosed via invasive biopsy, underscoring the need for non-invasive alternatives. This study identifies biologically relevant extrace...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Aleksandra Leszczynska, Benedikt Kaufmann, Hana Sung, Christian Stoess, Agustina Reca, Andrea Kim, Yeon-Kyung Choi, Chelsea Tran, Sung-Eun Kim, Davide Povero, Bruce Wolfe, Trevor Crafts, Akiko Eguchi, Ariel E. Feldstein
Format:	Article
Language:	English
Published:	Nature Portfolio 2026-06-01
Subjects:	Extracellular vesicles Metabolic dysfunction-associated steatotic liver disease (MASLD) Metabolic dysfunction-associated steatohepatitis (MASH) Organoids Machine learning Precision medicine
Online Access:	https://doi.org/10.1038/s41598-026-40490-x