Inhibiting WEE1 Augments the Antitumor Efficacy of Cisplatin in Urothelial Carcinoma by Enhancing the DNA Damage Process

Urothelial carcinoma (UC) is characterized by a high incidence of <i>TP53</i> mutation, and overcoming resistance to cisplatin-based chemotherapy in UC is a major concern. Wee1 is a G2/M phase regulator that controls the DNA damage response to chemotherapy in <i>TP53</i>-muta...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Cells
المؤلفون الرئيسيون:	Yu-Li Su, Ling-Yi Xiao, Shih-Yu Huang, Chia-Che Wu, Li-Chung Chang, Yi-Hua Chen, Hao-Lun Luo, Chun-Chieh Huang, Ting-Ting Liu, Jei-Ming Peng
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2023-05-01
الموضوعات:	WEE1 urothelial carcinoma chemotherapy DNA damage cell cycle <i>TP53</i> mutation
الوصول للمادة أونلاين:	https://www.mdpi.com/2073-4409/12/11/1471