Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis

Abstract Osteosarcoma (OS), a highly malignant primary bone tumor, is characterized by early metastasis, drug resistance, and a resultant poor prognosis, leading to significant disability and mortality. While diverse treatment modalities exist, their therapeutic efficacy remains limited, underscorin...

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發表在:	Scientific Reports
Main Authors:	Qingqing Qin, Huaibin Zhang, Min Lai, Jiantong Wei, Jun Qian, Xingchao Chen, Xin Wang, Yongping Wang
格式:	Article
語言:	英语
出版:	Nature Portfolio 2025-08-01
主題:	Osteosarcoma Sulfasalazine Ferroptosis NRF2 SLC7A11 GPX4
在線閱讀:	https://doi.org/10.1038/s41598-025-13324-5