Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide

Inhibition of protein deacetylation enzymes, alone or in combination with standard chemotherapies, is an exciting addition to cancer therapy. We have investigated the effect of deacetylase inhibition on the metabolism of glioblastoma cells. 1H NMR metabolomics analysis was used to determine the majo...

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Bibliographic Details

Published in:	Metabolites
Main Authors:	Miroslava Cuperlovic-Culf, Mohamed Touaibia, Patrick-Denis St-Coeur, Julie Poitras, Pier Morin, Adrian S. Culf
Format:	Article
Language:	English
Published:	MDPI AG 2014-09-01
Subjects:	metaboloepigenomics NMR metabolomics glioblastoma enzyme inhibitors combined treatment
Online Access:	http://www.mdpi.com/2218-1989/4/3/807