PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study

Abstract Background Fluoropyrimidine-based postoperative adjuvant chemotherapy is globally recommended for high-risk stage II and stage III colon cancer. However, adjuvant chemotherapy is often associated with severe adverse events and is not highly effective in preventing recurrence. Therefore, dis...

Full description

Bibliographic Details

Published in:	BMC Gastroenterology
Main Authors:	Yoshiaki Mihara, Masataka Hirasaki, Yosuke Horita, Takashi Fujino, Hisayo Fukushima, Yasuo Kamakura, Kousuke Uranishi, Yasumitsu Hirano, Shomei Ryozawa, Masanori Yasuda, Yoshinori Makino, Satomi Shibazaki, Tetsuya Hamaguchi
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	Colorectal cancer 5-FU Adjuvant chemotherapy Biomarker PINK1
Online Access:	https://doi.org/10.1186/s12876-023-02975-1