Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpene 1,3-Aminoalcohol Regioisomers

A series of novel diterpene-type 1,3-aminoalcohols and their regioisomers have been synthesised from natural stevioside in a stereoselective manner. The key intermediate β-keto alcohol was prepared using Wagner–Meerwein rearrangement of the epoxide derived from steviol methyl ester. The primary amin...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Dorottya Bai, Zsuzsanna Schelz, Mária Fanni Boncz, István Zupkó, Zsolt Szakonyi
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	diterpene steviol aminoalcohol stereoselective regioisomer antiproliferative activity
Online Access:	https://www.mdpi.com/1420-3049/28/24/7962