Box–Behnken Assisted HPLC Development of Simultaneous Determination of Doxorubicin and Vorinostat Encapsulated into Polymeric Nanoparticles

The objects of the present study are nanoparticles (NPs) based on a copolymer of lactic and glycolic acids (PLGA), loaded with the anticancer drug doxorubicin (DOX-NP) and histone deacetylase inhibitor vorinostat (SAHA-NP) and developed for breast cancer treatment [...]

Bibliographic Details

Published in:	Medical Sciences Forum
Main Authors:	Maria Sokol, Ivan Gulyaev, Mariia Mollaeva, Sergey Kuznetsov, Vladimir Zenin, Maksim Klimenko, Nikita Yabbarov, Margarita Chirkina, Elena Nikolskaya
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	Box–Behnken design doxorubicin nanoparticles PLGA validation vorinostat
Online Access:	https://www.mdpi.com/2673-9992/14/1/136