scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells

Abstract Extrachromosomal circular DNAs (eccDNAs) have emerged as important intra-cellular mobile genetic elements that affect gene copy number and exert in trans regulatory roles within the cell nucleus. Here, we describe scCircle-seq, a method for profiling eccDNAs and unraveling their diversity a...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Jinxin Phaedo Chen, Constantin Diekmann, Honggui Wu, Chong Chen, Giulia Della Chiara, Enrico Berrino, Konstantinos L. Georgiadis, Britta A. M. Bouwman, Mohit Virdi, Luuk Harbers, Sara Erika Bellomo, Caterina Marchiò, Magda Bienko, Nicola Crosetto
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Online Access:	https://doi.org/10.1038/s41467-024-45972-y