The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a reducing agent. GPX4 has become a hotspot ther...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Kamari Weaver, Rachid Skouta
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Subjects:	selenoprotein glutathione peroxidase 4 (GPX4) reduced glutathione (GSH) ferroptosis lipid peroxidation ferroptosis modulators small molecules targeting GPX4
Online Access:	https://www.mdpi.com/2227-9059/10/4/891