Ionizing radiation effects on blood-derived extracellular vesicles: insights into miR-34a-5p-mediated cellular responses and biomarker potential

Abstract Adverse effects of ionizing radiation on normal tissues limit the radiation dose in cancer treatment, thereby compromising treatment efficiency. Among the consistently affected non-cancer cells, peripheral blood mononuclear cells (PBMCs) exhibit high radiosensitivity and have the potential...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Chiara Huber, Omar Elsaeed, Pia Lahmer, Simone Moertl
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	MiR-34a-5p Keratinocytes Exosomes Intercellular communication PBMC Bystander effect
Online Access:	https://doi.org/10.1186/s12964-024-01845-x