Two-stage group-sequential designs with delayed responses – what is the point of applying corresponding methods?

Abstract Background In group-sequential designs, it is typically assumed that there is no time gap between patient enrollment and outcome measurement in clinical trials. However, in practice, there is usually a lag between the two time points. This can affect the statistical analysis of the data, es...

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Bibliographic Details
Published in:BMC Medical Research Methodology
Main Authors: Stephen Schüürhuis, Gernot Wassmer, Meinhard Kieser, Friedrich Pahlke, Cornelia Ursula Kunz, Carolin Herrmann
Format: Article
Language:English
Published: BMC 2024-10-01
Subjects:
Group-sequential design
Delayed response
Pipeline data
Performance evaluation
Conditional performance score
rpact
Online Access:https://doi.org/10.1186/s12874-024-02363-7

Internet

https://doi.org/10.1186/s12874-024-02363-7

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