Transmembrane protein CD69 acts as an S1PR1 agonist
The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector activity. Multiple drugs that inhibit S1PR1 function are in use clinically for the treatment of autoimmune diseases. Clu...
| Published in: | eLife |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-04-01
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| Subjects: | |
| Online Access: | https://elifesciences.org/articles/88204 |