Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Abstract Background Due to its neurotoxic properties, oligomeric alpha-synuclein (α-syn) has been suggested as an attractive target for passive immunization against Parkinson’s disease (PD). In mouse models of PD, antibody treatment has been shown to lower the levels of pathogenic α-syn species, inc...

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出版年:	Journal of Neuroinflammation
主要な著者:	Gabriel Gustafsson, Veronica Lindström, Jinar Rostami, Eva Nordström, Lars Lannfelt, Joakim Bergström, Martin Ingelsson, Anna Erlandsson
フォーマット:	論文
言語:	英語
出版事項:	BMC 2017-12-01
主題:	α-synuclein oligomers Astrocytes Antibodies Mitochondria Lysosomal degradation Parkinson’s disease
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12974-017-1018-z