Cancer-Associated-Fibroblast-Mediated Paracrine and Autocrine SDF-1/CXCR4 Signaling Promotes Stemness and Aggressiveness of Colorectal Cancers

Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide, and cancer-associated fibroblasts (CAFs) play a major role in the tumor microenvironment (TME), which facilitates the progression of CRC. It is critical to understand how CAFs promote the progression of CRC for the development...

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Bibliographic Details

Published in:	Cells
Main Authors:	Chao-Yang Chen, Shih-Hsien Yang, Ping-Ying Chang, Su-Feng Chen, Shin Nieh, Wen-Yen Huang, Yu-Chun Lin, Oscar Kuang-Sheng Lee
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Subjects:	cancer-associated fibroblasts (CAFs) stromal-derived factor-1 (SDF-1) C-X-C motif chemokine receptor 4 (CXCR4) tumor microenvironment (TME) cancer stem cells (CSCs)
Online Access:	https://www.mdpi.com/2073-4409/13/16/1334