Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade

Abstract Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whether ABCs from different conditions are similar and...

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發表在:	Nature Communications
Main Authors:	Juan Carlos Yam-Puc, Zhaleh Hosseini, Emily C. Horner, Pehuén Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O’Reilly, Harry Robson, Lucy H. Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie Kingston, Thomas E. Mulroney, Lucia P. G. Piñon, CITIID-NIHR COVID−19 BioResource Collaboration, Michael A. Chapman, Sofia Grigoriadou, Marion MacFarlane, Anne E. Willis, Kiran R. Patil, Sarah Spencer, Emily Staples, Klaus Warnatz, Matthew S. Buckland, Florian Hollfelder, Marko Hyvönen, Rainer Döffinger, Christine Parkinson, Sara Lear, Nicholas J. Matheson, James E. D. Thaventhiran
格式:	Article
語言:	英语
出版:	Nature Portfolio 2023-06-01
在線閱讀:	https://doi.org/10.1038/s41467-023-38810-0