p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape

The Shc family adaptor p66Shc acts as a negative regulator of proliferative and survival signals triggered by the B-cell receptor and, by enhancing the production of reactive oxygen species, promotes oxidative stress-dependent apoptosis. Additionally, p66Shc controls the expression and function of c...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Laura Patrussi, Nagaja Capitani, Cristina Ulivieri, Noemi Manganaro, Massimo Granai, Francesca Cattaneo, Anna Kabanova, Lucia Mundo, Stefania Gobessi, Federica Frezzato, Andrea Visentin, Francesca Finetti, Pier Giuseppe Pelicci, Mario M. D’Elios, Livio Trentin, Gianpietro Semenzato, Lorenzo Leoncini, Dimitar G. Efremov, Cosima T. Baldari
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2019-10-01
Online Access:	https://haematologica.org/article/view/9087