ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer

Abstract Background Colorectal cancer (CRC) is considered the third most common type of cancer worldwide. Tumor-associated macrophages (TAMs) have been shown to promote drug resistance. Adenosine-to-inosine RNA-editing, as regulated by adenosine deaminase acting on RNA (ADAR), is a process that indu...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Hibiki Umeda, Kunitoshi Shigeyasu, Toshiaki Takahashi, Kazuya Moriwake, Yoshitaka Kondo, Kazuhiro Yoshida, Sho Takeda, Shuya Yano, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Hideki Yamamoto, Kosei Takagi, Masashi Kayano, Hiroyuki Michiue, Keiichiro Nakamura, Yoshiko Mori, Fuminori Teraishi, Hiroshi Tazawa, Yuzo Umeda, Shunsuke Kagawa, Ajay Goel, Toshiyoshi Fujiwara
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	RNA-editing Macrophage Chemoresistance Biomarker Colorectal cancer
Online Access:	https://doi.org/10.1186/s12943-025-02312-y