Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice

Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. Here, we investigated the role of FXR in the high-dose OCA-induced hepatoxicity in the condi...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Chuangzhen Lin, Bingqing Yu, Lixin Chen, Zhaohui Zhang, Weixiang Ye, Hui Zhong, Wenke Bai, Yuping Yang, Biao Nie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Subjects:	nonalcoholic fatty liver disease (NAFLD) obeticholic acid (OCA) farnesoid X receptor (FXR) hepatic fibrosis interleukin -1β
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.880508/full