Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome

E3 ubiquitin ligases engage their substrates via ‘degrons’ - short linear motifs typically located within intrinsically disordered regions of substrates. As these enzymes are large, multi-subunit complexes that generally lack natural small-molecule ligands and are difficult to inhibit via convention...

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Bibliographic Details

Published in:	eLife
Main Authors:	Rohan Eapen, Cynthia Okoye, Christopher Stubbs, Marianne Schimpl, Thomas Tischer, Eileen J Fisher, Maria Zacharopoulou, Fernando Ferrer, David Barford, David R Spring, Catherine Lindon, Christopher Phillips, Laura S Itzhaki
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-09-01
Subjects:	anaphase-promoting complex/cyclosome APC/C peptide inhibitor protein–protein interaction degron ubiquitin
Online Access:	https://elifesciences.org/articles/104238