Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis

Introduction: Pulmonary fibrosis (PF) is a fatal fibrotic lung disease without any options to halt disease progression. Feasible evidence suggests that aberrant metabolism of amino acids may play a role in the pathoetiology of PF. However, the exact impact of kynurenine (Kyn), a metabolite derived f...

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Bibliographic Details

Published in:	Journal of Advanced Research
Main Authors:	Yi Wang, Guo-Rao Wu, Huihui Yue, Qing Zhou, Lei Zhang, Long He, Weikuan Gu, Rongfen Gao, Lingli Dong, Huilan Zhang, Jianping Zhao, Xiansheng Liu, Weining Xiong, Cong-Yi Wang
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	Pulmonary fibrosis Indoleamine 2,3-dioxygenase 1 Tryptophan Kynurenine Fibroblasts
Online Access:	http://www.sciencedirect.com/science/article/pii/S2090123224002546