Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

Abstract Fibrotic diseases cause organ failure that lead to ~45% of all deaths in the United States. Activated macrophages stimulate fibrosis by secreting cytokines that induce fibroblasts to synthesize collagen and extracellular matrix proteins. Although suppression of macrophage‐derived cytokine p...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Fenghua Zhang, Ehab A Ayaub, Bingbing Wang, Estela Puchulu‐Campanella, Yen‐Hsing Li, Suraj U Hettiarachchi, Spencer D Lindeman, Qian Luo, Sasmita Rout, Madduri Srinivasarao, Abigail Cox, Konstantin Tsoyi, Cheryl Nickerson‐Nutter, Ivan O Rosas, Philip S Low
Format:	Article
Language:	English
Published:	Springer Nature 2020-06-01
Subjects:	bleomycin folate receptor β idiopathic pulmonary fibrosis macrophages toll‐like receptor 7
Online Access:	https://doi.org/10.15252/emmm.202012034