Reciprocal negative feedback between Prrx1 and miR-140-3p regulates rapid chondrogenesis in the regenerating antler

Abstract During growth phase, antlers exhibit a very rapid rate of chondrogenesis. The antler is formed from its growth center reserve mesenchyme (RM) cells, which have been found to be the derivatives of paired related homeobox 1 (Prrx1)-positive periosteal cells. However, the underlying mechanism...

Full description

Bibliographic Details

Published in:	Cellular & Molecular Biology Letters
Main Authors:	Pengfei Hu, Guokun Zhang, Hengxing Ba, Jing Ren, Jiping Li, Zhen Wang, Chunyi Li
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Chondrogenesis Antler miR-140-3p Prrx1 Negative feedback
Online Access:	https://doi.org/10.1186/s11658-024-00573-x