Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6

Abstract Parkinson’s disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson’s. We report that nicotine reduces the abundance of SIRT6 in neurona...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Justin W. Nicholatos, Adam B. Francisco, Carolyn A. Bender, Tiffany Yeh, Fraz J. Lugay, Jairo E. Salazar, Christin Glorioso, Sergiy Libert
Format:	Article
Language:	English
Published:	BMC 2018-11-01
Subjects:	Parkinson’s disease SIRT6 Nicotine Neuroprotection Neurodegeneration Cell death
Online Access:	http://link.springer.com/article/10.1186/s40478-018-0625-y