Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers

Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate. Structural aberrations that promote activation of the alternative lengthening of...

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Bibliographic Details

Published in:	Open Biology
Main Authors:	Robert Lu, Hilda A. Pickett
Format:	Article
Language:	English
Published:	The Royal Society 2022-03-01
Subjects:	telomere maintenance replication stress alternative lengthening of telomeres ALT
Online Access:	https://royalsocietypublishing.org/doi/10.1098/rsob.220011