Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

Objective The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mutations and BRCA1 methylation in women with OC. Met...

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出版年:	Obstetrics & Gynecology Science
主要な著者:	Roshni D. Kalachand, Ciaran O’Riain, Sinead Toomey, Aoife Carr, Kirsten M. Timms, Sharon O’Toole, Stephen Madden, Mark Bates, John J. O’Leary, Noreen Gleeson, Dearbhaile O’Donnell, Liam Grogan, Oscar Breathnach, Angela Farrelly, Britta Stordal, Bryan T. Hennessy
フォーマット:	論文
言語:	英語
出版事項:	Korean Society of Obstetrics and Gynecology 2020-09-01
主題:	ovarian cancer methylation mutation
オンライン･アクセス:	http://www.ogscience.org/upload/pdf/ogs-20033.pdf