Physicochemical properties and cytochromes P-450 kinetics of a trifluoroacetamido derivative of acetaminophen

Acetaminophen (N-acetyl-para-aminophenol, APAP) is a commonly used analgesic and antipyretic drug. While acetaminophen is generally safe when taken at therapeutic doses, it causes severe liver and kidney damage at overdose quantities. Cytochromes P-450 (CYP) catalyze the transformation of APAP to N-...

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Bibliographic Details

Published in:	Results in Chemistry
Main Authors:	Joshua A. Boldon, Thomas A. Shell
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Acetaminophen Paracetemol Fluorine Derivative Lipophilicity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715623003685