HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression

Background The advent of immune checkpoint blockade antibodies has demonstrated that effective mobilization of T cell responses can cause tumor regression of metastatic cancers, although these responses are heterogeneous and restricted to certain histologic types of cancer. To enhance these response...

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Bibliographic Details

Published in:	Journal for ImmunoTherapy of Cancer
Main Authors:	Tao Wang, Herbert Kim Lyerly, Alan Chen Chen, Renhuan Xu, Junping Wei, Xiao-Yi Yang, Cong-Xiao Liu, Gangjun Lei, Teri Heiland, Zachary Conrad Hartman
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2020-05-01
Online Access:	https://jitc.bmj.com/content/8/1/e000258.full