Comparative effectiveness of methadone versus buprenorphine/naloxone during pregnancy on perinatal and neonatal health outcomes: protocol for a population-based target trial in British Columbia, Canada

Introduction Opioid use disorder (OUD) during pregnancy is associated with increased rates of adverse perinatal, foetal and neonatal health events. Opioid agonist treatment (OAT) can substantially reduce the risk of these potential harms. In British Columbia (BC), methadone and buprenorphine/naloxon...

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Bibliographic Details

Published in:	BMJ Open
Main Authors:	Lianping Ti, Bohdan Nosyk, Jeong Eun Min, B Carolina Guerra-Alejos, Megan Kurz, Lindsay A Wilson
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-08-01
Online Access:	https://bmjopen.bmj.com/content/15/8/e095461.full