Low-Concentration Methylene Blue Maintains Energy Production and Strongly Improves Survival of Leigh Syndrome French Canadian Skin Fibroblasts

Abstract - Leigh syndrome French Canadian (LSFC) is a recessive disease caused by mutations in the LRPPRC gene (leucine-rich pentatricopeptide repeat containing protein). These mutations induce a cytochrome c oxidase (COX) deficiency resulting in episodes of acute acidotic crisis that will often lea...

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Bibliographic Details

Published in:	Journal of Pharmacy & Pharmaceutical Sciences
Main Authors:	Jean Legault, Pierre-Luc Larouche, Isabelle Côté, Line Bouchard, André Pichette, Brian H Robinson, Charles Morin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-12-01
Online Access:	https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/11209