Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. Mutation of proline-rich transmembrane protein 2 (PRRT2), a regulator o...

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Bibliographic Details

Published in:	eLife
Main Authors:	Kazi Rahman, Charles A Coomer, Saliha Majdoul, Selena Y Ding, Sergi Padilla-Parra, Alex A Compton
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-10-01
Subjects:	membrane oligomerization IFITM virus PRRT2 fusion
Online Access:	https://elifesciences.org/articles/58537