Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria

ABSTRACT While highly effective at killing Gram-positive bacteria, auranofin lacks significant activity against Gram-negative species for reasons that largely remain unclear. Here, we aimed to elucidate the molecular mechanisms underlying the low susceptibility of the Gram-negative model organism Es...

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書誌詳細

出版年:	Microbiology Spectrum
主要な著者:	Laísa Quadros Barsé, Agnes Ulfig, Marharyta Varatnitskaya, Melissa Vázquez-Hernández, Jihyun Yoo, Astrid M. Imann, Natalie Lupilov, Marina Fischer, Katja Becker, Julia E. Bandow, Lars I. Leichert
フォーマット:	論文
言語:	英語
出版事項:	American Society for Microbiology 2024-11-01
主題:	auranofin gold drug repurposing thioredoxin reductase proteomics Escherichia coli
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/spectrum.00138-24