Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis

BackgroundWe have previously demonstrated that hydrogen sulfide (H2S) is sufficient to attenuate depressive-like behavior induced by chronic unpredictable mild stress (CUMS), but its underlying mechanisms remain largely unknown. It is well known that necroptosis is a trigger of inflammation and neur...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	San-Qiao Yang, Yu-Hui Tang, Si-Min Chen, Fen Liu, Ping Zhang, Wei Zou, Bo Wang, Xiao-Qing Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	H2S depression necroptosis neuroinflammation kynurenine pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1691204/full