Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

Wnt/β-catenin signal transduction directs intestinal stem cell (ISC) proliferation during homeostasis. Hyperactivation of Wnt signaling initiates colorectal cancer, which most frequently results from truncation of the tumor suppressor Adenomatous polyposis coli (APC). The β-catenin-TCF transcription...

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Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	Ai Tian, Hassina Benchabane, Zhenghan Wang, Chloe Zimmerman, Nan Xin, Jessica Perochon, Gabriela Kalna, Owen J Sansom, Chao Cheng, Julia B Cordero, Yashi Ahmed
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-07-01
Online Access:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006870&type=printable