ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways

Consumption of a high fat diet (HFD) is linked to metabolic syndrome and cognitive impairments. This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for Alzheimer’s disease (AD). Apolipoprotein E (apoE) is involved in cholesterol metabolism. In humans, th...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Payel Kundu, Sarah Holden, Ines L. Paraiso, Reetesh Sudhakar, Chloe McQuesten, Jaewoo Choi, Cristobal L. Miranda, Claudia S. Maier, Gerd Bobe, Jan F. Stevens, Jacob Raber
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	xanthohumol high-fat diet cognition metabolic syndrome APOE metabolomics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.954980/full