Global deletion of COX-2 attenuates hepatic inflammation but impairs metabolic homeostasis in diet-induced obesity

The role of cyclooxygenase-2 (COX-2), a well-known pharmacological target for attenuating inflammation, in regulating obesity and its comorbidities remains unclear. We sought to determine the role of COX-2 in modulating metabolic inflammation and systemic metabolic homeostasis in obesity. Male WT an...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Jeyakumar Balakrishnan, Cyrus Desouza, Rishikesh Thakare, Yazen Alnouti, Viswanathan Saraswathi
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	COX-2 MASLD obesity inflammation triglycerides cholesterol
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227525000835